https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Exposure to estrogenic mixtures results in tissue-specific alterations to the metabolome of oysters https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48379 Saccostrea glomerata. Oysters were exposed to a “low” and a “high” mixture of (xeno) estrogens (representative of Australian and global receiving waters respectively) for 7 days and digestive gland, gill, and gonad tissue were sampled for quantification of polar metabolites by ¹H NMR spectroscopy. Exposure to both mixtures lowered body mass and altered the metabolite profile in the digestive glands. Comparatively, gills, and ovaries demonstrated lesser sensitivity to the mixtures, with significant metabolomic alterations observed only for the high mixture. The male gonad did not respond to either estrogenic exposure. In the responsive tissues, major metabolites including amino acids, carbohydrates, intermediates of the tricarboxylic acid cycle and ATP were all down-regulated and exhibited tissue-specific patterns of down-regulation with the greatest proportion of metabolites down-regulated due to estrogenic exposure in the digestive gland. Exposure to (xeno) estrogen mixtures representative of concentrations reported in receiving waters in Australia and globally can impact the metabolome and associated energy metabolism, especially in the digestive gland, translating to lower pools of available ATP energy for potential cellular homeostasis, somatic maintenance and growth, reproduction and fitness.]]> Wed 15 Mar 2023 14:50:37 AEDT ]]> Estrogenic mixtures induce alterations in lipidomic profiles in the gonads of female oysters https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47121 Wed 14 Dec 2022 12:32:24 AEDT ]]> Molluscan biomonitor for quantification and impact assessment of estrogenic and metallic contaminants in Australian marine ecosystems https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9323 Wed 11 Apr 2018 15:21:23 AEST ]]> Secondary treatment phase of tertiary wastewater treatment works significantly reduces estrogenic load https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39440 Wed 07 Jun 2023 10:32:24 AEST ]]> Benthic infaunal assemblages adjacent to an ocean outfall in Australian marine waters: Impact assessment and identification of indicator taxa https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46223 Mon 14 Nov 2022 12:11:57 AEDT ]]> Parental exposure to the synthetic estrogen 17a-ethinylestradiol (EE2) affects offspring development in the Sydney rock oyster, Saccostrea glomerata https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43556 Fri 23 Sep 2022 10:33:22 AEST ]]> The utility of vitellogenin as a biomarker of estrogenic endocrine disrupting chemicals in molluscs https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34757 Fri 05 May 2023 15:48:50 AEST ]]>